Herein, we describe the synthesis of bench-stable organometallic Au(III) terminated polymer reagents. These reagents mediate the chemoselective S-arylation of thiol-containing small molecules and polymers to yield functionalized mono-telechelic polymers and diblock copolymers, respectively. These transformations proceed rapidly within minutes and produce conjugates in quantitative conversion, making

Transition metal-catalyzed asymmetric nitrene transfer is a powerful method for the generation of enantioenriched amines found in natural products and bioactive molecules. We report herein a highly chemo- and enantioselective intramolecular silver-catalysed aziridination that employs 2,2,2-trichloroethoxysulfonyl (Tces)-protected carbamimidates as an underexplored class of nitrene precursors. In contrast

This study presents an injectable cell-laden hydrogel system based on silk acid, a carboxylated derivative of natural silk fibroin, which exhibits promising applications in biomedicine. The hydrogel is produced under physiological conditions (37 °C and pH 7.4) via physical crosslinking. Notably, the hydrogel demonstrates remarkable cytocompatibility, enabling efficient cell encapsulation, and exhibits

The concept of a quasi-bound state in a continuum (QBIC) has garnered significant attention in various fields such as sensing, communication, and optical switching. Within metasurfaces, QBICs offer a reliable platform that enables sensing capabilities through potent interactions between local electric fields and matter. Herein, we report a novel terahertz (THz) biosensor based on the integration of

In this paper, a novel optical logic operator based on the multifunctional metasurface driven by all-optical diffractive neural network is reported, which can perform four principal quantum logic operations (Pauli-X, Pauli-Y, Pauli-Z and Hadamard gates). The two ground states |0〉 and |1〉?are characterized by two orthogonal linear polarization states. The proposed spatial- and polarization-multiplexed

Nickel oxide (NiOx) has garnered considerable attention as a prospective hole-transporting layer (HTL) in organic solar cells (OSCs), offering a potential solution to the stability challenges posed by traditional HTL, PEDOT:PSS, arising from acidity and hygroscopicity. Nevertheless, lower work function (WF) of NiOx relative to donor polymers reduces charge injection efficiency in OSCs. Herein, we tailor

The use of light as a powerful tool for disease treatment has introduced a new era in tumor treatment and provided abundant opportunities for light-based tumor theranostics. This work reports a photothermal theranostic fiber integrating cancer detection and therapeutic functions. Its self-heating effect can be tuned at ultralow powers and used for self-heating detection and tumor ablation. The fiber

Numerous bio-organisms employ template-assisted crystallization of molecular solids to yield crystal morphologies with unique optical properties that are difficult to reproduce synthetically. Here, we present a facile procedure to deposit bio-inspired birefringent crystals of xanthine derivatives on a template of single-crystal quartz. We obtain crystalline sheets that are several millimeters in length

Stroke is the primary cause of disability without effective rehabilitation methods. Emerging brain–machine interfaces offer promise for regulating brain neural circuits and promoting the recovery of brain function disorders. Implantable probes play key roles in brain–machine interfaces, which are subject to two irreconcilable tradeoffs between conductivity and modulus match/transparency. In this work

Interfaces in perovskite solar cells (PSCs) play a pivotal role in determining device performance by influencing charge transport and recombination. Understanding the physical processes at these interfaces is essential for achieving high-power conversion efficiency in PSCs. Particularly, the interfaces involving oxide-based transport layers are susceptible to defects like dangling bonds, excess oxygen

Bioimaging is a powerful tool for diagnosing tumors but remains limited in terms of sensitivity and specificity. Nanotechnology-based imaging probes able to accommodate abundant imaging units with different imaging modalities are particularly promising for overcoming these limitations. In addition, the nanosized imaging agents can specifically increase the contrast of tumors by exploiting the enhanced

Quantum dots are nanometre-sized semiconducting crystals. While chemists tend to interrogate molecular structure to understand properties, and materials physicists might interrogate the composition and bulk structure of larger crystals, scientists must pay close attention to the size of quantum dots to understand their behaviour. This is because of quantum confinement effects, which can be used to

Becoming an assistant professor brings with it numerous challenges, one of which is teaching undergraduate courses for the first time. Shira Joudan reflects on the ups and downs of setting up and delivering her first course.

Daniel Rabinovich outlines the story of insulin, the essential drug for the treatment of diabetes during the past century.

The ‘anthrobots’ were able to repair a scratch in a layer of neurons in the lab.

The whole genomes of 500,000 people in the UK Biobank will help researchers to probe our genetic code for links to disease.

The expansion of the neocortex, a hallmark of mammalian evolution1,2, was accompanied by an increase in cerebellar neuron numbers3. However, little is known about the evolution of the cellular programs underlying cerebellum development in mammals. In this study, we generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in

Hear the biggest stories from the world of science | 29 November 2023